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Differentiation 108, 2432

Amyotrophic Lateral Sclerosis The primary characteristic of the deadly neurodegenerative disease known as ALS is the selective degeneration of both the brain's upper and lower motor neurons as well as those in the brain stem and spinal cord [247, 248]

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Thus, roGFP2 oxidation does not efficiently occur via a Grx(SSR) intermediate and we can exclude the dithiol mechanism and monothiol mechanism (i) for roGFP2 oxidation (reverse reactions in Fig

Grip Strength Testing : Comparing grip strength between hands using a dynamometer provides objective evidence of motor weakness