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Activation of ERK is dependent on the RAS/MAPK pathway, in which IIS results in phosphorylated IRS or SHC that recruit growth factor receptor-bound protein 2 (GRB-2)

The protein concentration of the supernatant was measured using a bicinchoninic acid protein assay

Nature 488, 499503

While excessive levels of ROS can cause apoptosis in cancer cells, moderate ROS levels promote tumor development and progression (49)

[DOI] [PubMed] [Google Scholar] 562.Niu W., Wu P., Chen F., Wang J., Shang X., Xu C
