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Monitoring and follow-up Monitor clinically and repeat tests as indicated by the underlying condition Ongoing monitoring of liver function, renal function, and FBC as clinically indicated Regular review in primary care or specialist clinics for underlying conditions Patient advice: Patients should understand that elevated B12 is a marker requiring investigation rather than a condition requiring direct treatment

10.3892/ijmm.2016.2593 26 ChenL.ZhangC.ChenL.WangX.XiangB.WuX.et al (2017a)

However, critical challenges emerge regarding speciesspecific dosage variations, longterm toxicity concerns and lack of regulatory frameworks

Skeletal muscles of mdx mice demonstrate increased quantities of oxidative damage markers including the by-products of lipid peroxidation and carbonyls (Haycock, Mac, & Mantle, 1998