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A 2025 systematic review and meta-analysis of the efficacy of various medications used to prevent or reduce ototoxicity in adults receiving cisplatin included eight studies with collectively 431 patients (six randomized controlled trials and two prospective cohort studies) of a wide range of potential otoprotective therapies: diethyldithiocarbamate (intravenously), dexamethasone (intratympanic), N-acetylcysteine (intratympanic), sodium thiosulfate (intravenously), calcium gluconate (intravenously), and aspirin (orally) (18)

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Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus

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