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[79] Brennan P, Hsu C, Lancet NMT

Conclusion We found a gestational-age-dependent increase in glucuronidation but no evidence for saturation of a specific pathway as there was a proportional increase in exposure of acetaminophen and all metabolites

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Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)

doi: 10.3389/fphar.2022.1048728 Received 19 September 2022 Accepted 25 October 2022 Published 08 November 2022 Volume 13 - 2022 Edited by Jinyong Peng, Dalian Medical University, China Reviewed by Li Lili, Anhui University of Chinese Medicine, China Pengyuan Sun, Dalian Medical University, China Updates Copyright 2022 Ma, Wang, Guo, Li, Liu and Zhao