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For patients with severe kidney disease, impaired renal function can affect how excess B12 is cleared from the body

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This is more likely if you have difficulty absorbing vitamin B12 through the digestion system and, therefore, need an injection directly into your muscles and blood

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The Short-Term Timeline: Days 3 to 7 By the end of the first week, the initial surge settles into a steadier supply of B12, and this is often when the more noticeable day-to-day changes appear

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