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Besides, the findings presented here illuminate a role for LROs in mounting systemic stress, detoxification, and antimicrobial defenses, which requires a co-operation between ancient and highly conserved processes such as compartmentalization in the endolysosomal system, an ABC membrane transporter and transcriptional stress and innate immune pathways

Attaching of N -Boc-norleucine, removal of Boc, acetylation of norleucine amino group with acetic anhydride, HF mediated cleavage of the resulting peptide from the polymer support, and finally purification using RP-HPLC afforded the target compound 2 in 5560% overall yield [18,24]

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