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High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU)

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Furthermore, it has been reported that opioids treatment induces gene expression alteration of several proteins such as neurotransmitters, mediators, and transcription factors, known to be involved in the long-term molecular and cellular adaptation occurring during tolerance and dependence [39]

doi: 10.3390/nu12082340 187 LukiIGetselterDKorenOElliottE

For a peptide-based medication, this is relatively contained, meaning tirzepatide stays concentrated rather than spreading thin across all body tissues