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Conclusion Evidence has shown that NNMT plays important roles in obesity and T2D and that NNMT inhibition significantly increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance and fasting blood glucose levels

35,38 For example, NS1 -methyl ester only reduced 30% of the 1-MNA level at 31.6 M

Some researchers eventually use up to 100mg daily for enhanced effects, though this should be approached gradually

There are a few reasons for this
