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Gain-of-function mutant p53: history and speculation
Loss of the p53 tumor suppressor impairs MDM2-mediated HIF-1 degradation by the proteasome, thus enhancing the transcriptional activation of VEGF 76
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While the flow cytometric apoptosis reduction (3.48%) was not statistically significant, the molecular markers (caspase-3 down 42.7%, PARP down 77.5%, Bcl-2/Bax shift) were all highly significant
