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In the empatic-360 group, 82.6% of patients lost at least 5% of their baseline body weight and 47.7% lost at least 10% of their baseline body weight as compared to 18.9% and 5.7% patients in the placebo group, respectively [192]

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There are remarkably few pharmacological interventions that actively promote brain repair after the acute phase stabilizes

2013;17(4):52531 Hawley MA

Approaches that suppress lactate production, such as using PDK inhibitors (DCA and thiamine), have been demonstrated to alleviate organ damage and mitigate ferroptosis in sepsis by reversing the pathological Warburg effect-like state, thereby improving mitochondrial function and reducing ROS accumulation (189,190)