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In proteins, tyrosine residues are often subjected to nitration with the formation of 3-nitrotyrosine (NT) [155]

As an illustration, it opposed hypertension and pro-thrombotic effects (L-NAME) [11,29,97,98,99], as well as hypotension and anti-thrombotic (L-arginine) effects [11,29,97,98,99]

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Beyond promoting detoxification via bile excretion, TUDCA offers cell-protective effects: it stabilizes mitochondrial membranes, reduces oxidative stress and endoplasmic-reticulum (ER) stress, and blocks apoptosis (cell death) in hepatocytes