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Interestingly, it was shown that highly metastatic melanoma cells can form their own vascular tubes to improve blood flow to the tumor site and promote cancer cell dissemination, a phenomenon known as vascular mimicry (76, 77)

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addition of RBV and/or extended therapy duration modestly increased SVR12 rates in these populations.[11] Current treatment guidelines recommend SOF + DCV with or without RBV for 24 weeks in patients with GT3 infection and compensated cirrhosis.[12, 13] The DAA combination of SOF and velpatasvir (VEL) for 12 weeks resulted in SVR12 rates between 89% and 91% for HCV GT3-infected patients with compensated cirrhosis and/or prior treatment experience.[14] The American Association for the Study of Liver Diseases recommends viral resistance testing prior to treatment with SOF/VEL in treatment-naive patients with compensated cirrhosis or in prior pegylated interferon (pegIFN)/RBV treatment-experienced patients without cirrhosis

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