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This finding has been controversial but a transcriptomic analysis of acutely isolated astrocytes has recently confirmed that PAG is indeed expressed by astrocytes (Lovatt et al

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Additionally, it has been reported that OS affects epigenetic regulatory mechanisms involved in the regulation of pancreatic cell survival and insulin secretion, like DNA methylation, chromatin architectural modification, and non-coding RNA (Kowluru and Mishra, 2017)