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Although, risperidone and aripiprazole are approved in the USA for the management of irritability and agitation in individuals with ASD, their clinical utility is constrained by an increased risk of adverse effects and limited efficacy in addressing core autistic symptoms [2, 3]

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In chronic pain and depression, morphological and functional neuroplastic changes were found most pronounced in fronto-limbic regions (Mutso et al., 2012

This is crucial because good blood flow ensures that oxygen and nutrients are efficiently delivered throughout the body, including to the heart
