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Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline

doi: 10.1016/S1470-2045(22)00606-4

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Therefore, we mutated surface-exposed cysteine residues of FBXO22 and measured their impact on 2- induced SMARCA2 degradation