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To support less frequent administration, site-specific lipidation or PEGylation was performed to prolong the duration of action of the unimolecular dual incretins
Activation of transcription factors: P-DSIP can induce the expression of transcription factors such as c-Fos and CREB, transmit membrane receptor signals to the nucleus, and regulate gene expression
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Our recent study addressing the metabolic milieu using untargeted lipidomics did find a sex-specific alteration in the lipidome at birth in the prenatal-T-treated offspring 29
The function of TFR2 in the liver is not to act in the uptake of transferrin-bound iron but to sense iron levels and to act as a regulator of hepcidin function
