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In parallel, zinc rapidly induces the expression and activation of lysosomal proteases cathepsin B and D, through early V-ATPase-dependent acidification and later TFEB-mediated transcription
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Key challenges hindering translation include identifying activators with optimal safety and pharmacokinetic profiles that allow for precise, selective, and temporal activation of Nrf2
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Liposomal cream is used in localized areas for inflammation, such as over the thyroid
