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CFTR mediates apoptotic volume decrease and cell death by controlling glutathione efflux and ROS production in cultured mice proximal tubules

Blocking this antioxidant axis with SLC7A11 and GPX4 inhibitors (ferroptosis inducers) such as the small-molecule Erastin and RSL3, respectively, leads to uncontrolled accumulation of lipid peroxides at the plasma membrane and other endomembranes within the cell, which promotes membrane permeabilization, damages membrane integrity and ultimately induces ferroptosis [34, 38]

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Many common foods and beverages contain phenol and hydroquinone

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