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Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors

NNMT inhibition increases intracellular concentrations of NAD + and SAM in differentiated adipocytes Figure 3A outlines the major elements of the mammalian NAD+ salvage pathway using NA as the starting substrate.[27] Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations (Figures 2B and 2C), we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD + salvage cycle

Suitable for studies involving peptide characterization and method development in model systems.Not for human use