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All events should be recorded, evaluated by study staff, and reported according to safety and ethics guidelines

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Cytokine change may induce alterations in neurotransmitter systems and neuronal integrity by inducing excitotoxic glutamate receptor-mediated damage, influencing monoaminergic systems [serotonin (5-HT), DA, and NE], -aminobutyric acid (GABA), acetylcholine, neuropeptides, and BDNF, which are directly associated with cognitive function and neurodegenerative processes (Wang et al., 2015)

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