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Tumors and major organs including heart, liver, spleen, lung, and kidney were isolated

N/A: The stated outcome was not discussed within the publication

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Moreover, oxidative stress can also influence the expression of proteins involved in iron metabolism, creating a feedback loop that accelerates cell death under the combined pressures of oxidative stress and iron metabolism imbalance (58)

A number of researchers have reported that the activation of the SphK1/S1P signaling pathway marks the occurrence of autoimmune diseases, and the up-regulation of SphK1 is related to the pathogenesis of multiple sclerosis (Luo et al., 2017)