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It functions as a potent vasodilator, modulates smooth muscle activity in the gastrointestinal tract, and participates in neurotransmission in the central and peripheral nervous systems (Lelievre et al., 2008)

Common symptoms of hormonal imbalances include mood swings, fatigue, weight fluctuations, irregular menstrual cycles, and sleep disturbances

M., Sen, N., Kim, S., Mu, W., Gazi, S

Pharmacovigilance analysis identified that patient age and body weight were significantly associated with gastrointestinal adverse event severity, with patients over 100 kg showing stronger signal strength for adverse events

the AnglV analog D Nle-Tyr-Ile-NH-(CH 2 ) 5-CONH2 is more metabolically stable than Norleual (Nle-Tyr-Leu -(CH 2 -NH 2 f- 4 -His-Pro Phe (SEQ ID NO: 1) the AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i CHj-NH -His-Pro-Phe (SEQ ID NO: 1)) D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats