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Opioids such as tramadol and tapentadol are also classified as secondline agents due to risks of developing dependence, respiratory depression, and potential abuse [336, 373]
Inositol, a common type of sugar present in the body, plays a pivotal role in speeding up metabolic processes and reducing blood cholesterol
Additionally, METTL3 enhanced chondrogenic differentiation of synovium-derived MSCs by targeting MMP3, MMP13, and GATA3 [128]
Geijtenbeek, T
Reducing A deposition through improved clearance mechanisms, alongside decreasing its production, represents a key therapeutic strategy
