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In addition to in vitro studies, in vivo studies in young animals also indicate that free glutamate can promote intestinal development

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[22] [23] For example, motexafin gadolinium (MGd) is a new chemotherapeutic agent that selectively targets tumor cells, leading to cell death and apoptosis via inhibition of thioredoxin reductase and ribonucleotide reductase

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Some ototoxic agents, such as aminoglycoside-targeting bacteria, also readily damage the mitochondria within cochlear hair cells, resulting in the release of pro-apoptotic factors and oxidative enzymes into the cytoplasm and, consequently, the generation of free radicals (Priuska and Schacht, 1995