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In the present study, it was found that the elevation of the above-mentioned pro-inflammatory markers were decreased by L-carnitine, and this inhibitory effect of L-carnitine was reversed by GW9662, suggesting that PPAR-dependent NF-B signaling is pivotal in the inflammatory response in cancer cachexia
To confirm these results, we knockeddown unc1 expression in a tissuespecific manner using RNAi by expressing doublestranded RNAs against the gene across the entire nervous system ( rab3 promoter) using transgenesis (Appendix Fig S8)

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Bladenboro Roberts, William Kinston Robertson, Harold R

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