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Key limitation: The intranasal route for bremelanotide was ultimately not pursued for regulatory approval due to the combination of lower and more variable bioavailability, higher incidence of blood pressure elevation, and less predictable pharmacokinetics compared with the subcutaneous route (reported in studies) [10] [17]

Glass R, Hope VD, Njoroge J, Edmundson C, Smith J, McVeigh J, et al

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These exceptions include LCoR (ligand-dependent nuclear-receptor corepressor), RIP140 (receptor-interacting protein-140) and REA (repressor of estrogen-receptor activity)

Front Neurosci 11:128 Can VC, Locke IC, Kaneva MK, Kerrigan MJP, Merlino F, De Pascale C, Grieco P, Getting SJ (2020) Novel anti-inflammatory and chondroprotective effects of the human melanocortin Mc1 receptor agonist Bms-470539 dihydrochloride and human melanocortin Mc3 receptor agonist Pg-990 on lipopolysaccharide activated chondrocytes