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There is no treatment available to cure and effectively reverse the progression of the disease, which may be related to its multi-faceted physiopathological mechanism [5]

As water enters the matrix, it hydrolyses the polymers ester bonds, releasing lactic and glycolic acids

Moreover, this diversion would be reflected by a reduction in serum holoTC and hence reduction in total serum vitamin B-12

Healy, J

NRF2 is the primary regulator of cell survival that raises cancer progression by protecting cancer cells from ROS and DNA damage ( ROS are implicated in cancer progression, promoting cyclin D1 expression, extracellular signal-regulated kinase (ERK) and JUN N-terminal kinase (JNK) phosphorylation, and MAPK activation (Saha et al., 2017)