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Pregnancy and breastfeeding are also contraindications due to insufficient safety data

We did not analyze possible sex influences in our study as in previous research, despite finding differences in immunity parameters between the sexes and higher mortality in males, as we did not find any differences in gut structure, function, or NEC incidence between males and females 26

In menstruating women, iron supplementation can help sustain optimal iron levels and reduce symptoms of low iron

There are still challenges to be addressed in the delivery of NPs, such as particle size, clearance by mucosal cilia, and degradation by proteases produced in vivo