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Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy

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doi: 10.1039/c6pp00442c

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In active demethylation, 5mC is converted into oxidized intermediates such as 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxycytosine (5caC), which can alter gene expression and cell function [337]

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CXCL1 is expressed by pericytes, perivascular macrophages and perivascular mast cells which could provide the earliest signal for neutrophil migration into the cochlea

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For example, Solenopsis invicta invades many countries, can increase their population, and dominates the local fauna (Morrison et al., 2004

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