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During mitochondrial biogenesis, the upstream signal regulators, silent information regulator 1 (SIRT1) and adenosine monophosphate-activated protein kinase (AMPK), activate PGC-1 through phosphorylation and deacetylation modifications

This hypothesis is supported by a tight connection between extrahepatic vitamin K deficiency and poor outcome [317]

doi: 10.1158/1055-9965.EPI-17-1136 240

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