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Our research has demonstrated that FOXO4-DRI can improve vascular function by alleviating endothelial cell senescence, providing a novel therapeutic approach for related diseases

In this depiction, each Cd(II) ion is tetra-coordinated by four cysteine ligands: two are deprotonated to yield (formally) Cd-thiolate conjugates that are similar in principle to those of glutathione and of other soluble thiols, while other two complete the coordination sphere

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Medable's platform has been deployed in Phase II and Phase III studies across oncology, CNS, respiratory, and rare disease indications, with a notable November 2024 partnership announced for deployment across an eight-EU-member-state oncology Phase III program