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In this respect astrocytes appear to play a key role in the GSH metabolism of the brain, since astroglial GSH export is essential for providing GSH precursors to neurons

For instance, curcumin has been shown to reduce amyloid plaque burden more effectively in APOE3 than in APOE4 transgenic mouse models (Far et al., 2024)

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Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors