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doi:10.1016/j.neuron.2017.02.022 23

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GSH is synthesized in two steps, both ATP-dependent processes, catalyzed by the enzymes GCL (glutamate-cysteine ligase, aka -glutamylcysteine synthetase) and glutathione synthetase, and is regenerated by six enzyme-catalyzed reactions, known as the -glutamyl cycle

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Most patients notice appetite suppression the same day within a few hours of the first dose