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Du Y, Piscitelli D, Ahmad S, Trahair L, Greenfield J, Samocha-Bonet D, Rayner C, Horowitz M, Jones K

Cells plated in glass-bottom 96-well plates were treated for the indicated times and, after fixation with 4% paraformaldehyde, images were acquired using a high-content microscope (Operetta, Perkin-Elmer)
The DNA lesions, in turn, trigger a series of signal-transduction pathways, leading to cell-cycle arrest, DNA repair and apoptosis
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