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HanSJHawkinsSMBegumKJungSYKovanciEQinJet al

This can result in an increased susceptibility to metabolic stress, a factor that greatly accelerates the aging process

This leads to the formation of lipid radicals and LOOH, which mainly decompose into MDA and 4-HNE, causing cytotoxic, genotoxic, and pro-inflammatory effects [8]

doi: 10.1186/s13287-020-02025-7 283 YuanXLiDChenXHanCXuLHuangTet al

Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response
