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In contrast, T-GSH content was positively correlated with the AsA content (r=0.72)
165,166 The N-terminus of APE1 facilitates proteinprotein interactions and redox activity, while the C-terminus mediates endonuclease activity
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Nevertheless, recent evidence implies that redox homeostasis is a central and primary mechanism in ALS and it may have greater importance than previously recognized (Sbodio et al., 2019

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