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Oral administration is physically possible, but without bioavailability data, there is no way to determine an effective oral dose or confirm that the compound is reaching target tissues

Nmnat3 is dispensable in mitochondrial NAD level maintenance in vivo

Mild nausea or bloating Occasionally reported when dosing begins but often subsides after a few days

Consultant haematologist Dr Priya Sriskandarajah published an article in Pulse Today including a link to a 2-hour CPD training course on key questions on vitamin B12 deficiency: CPD: Key questions on vitamin B12 deficiency

Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial ~35% decrease ( P 30% decrease in adipocyte size ( P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice