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Cancer cells can become protected from cytotoxic agents by manipulating the TME, which allows cancer cells to develop acquired resistance, resulting in disease relapse

de Arruda, I

Induction of cell cycle arrest In normal cells, the cell cycle is tightly regulated to ensure faithful DNA replication and chromosomal segregation prior to cell division

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A common process condition optimization method, Box-Behnken design, was used to optimize the operating variables such as temperature, pH, and enzyme quantity [34]