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Combining with Other Ingredients (Retinoids, Acids) Although copper peptides promote repair and collagen synthesis, avoid simultaneous use with highly irritating ingredients: Retinoids (Vitamin A derivatives): Can accelerate exfoliation and may react with copper ions, increasing irritation

F344 rats treated with pipermethystine (10 mg/kg) for 2 weeks resulted in significant increase in hepatic glutathione, cytosolic superoxide dismutase (Cu/ZnSOD), tumor necrosis factor alpha mRNA expression, and cytochrome P450 (CYP) 2E1 and 1A2, suggesting that pipermethystine caused adaptation to oxidative stress and possible drug-drug interactions (10)

This peptide may enhance skin regeneration, collagen production, and tissue repair

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For folding, RNA was incubated at 95 C and cooled to 4 C at 6 C/s on a ProFlex Thermal Cycler