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The synthesis in extrapineal sites presumably does not follow circadian rhythms, except for the retina, and mainly works as a local antioxidant 15,16

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The uncontrolled generation of ROS non-selectively attacks vulnerable phospholipids in the membranes of intestinal epithelial cellsaffecting both bacterial and host cellsresulting in epithelial injury, increased mucosal permeability, and ultimately barrier dysfunction (Laforgia et al., 2018)

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FIGURE 1 Mechanisms of Homocysteine-Induced Cognitive Impairment Posttranslational Modification of Proteins As mentioned above, homocysteine is produced in all cells