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In all isoforms enzymatic function depends on the conserved peroxidatic cysteine residue contained within an active-site conserved across all isoforms as well as cysteine in the carboxy-terminal region functional in some of the PRDX isoforms
The GCLC-KO mouse brain displays severe neuroinflammation at an early stage of brain atrophy Numerous studies have noted the importance of neuroinflammation in neurodegenerative processes 20
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