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[DOI] [PubMed] [Google Scholar] McLean J

S., Eccles C., et al

Although there was no effect on sperm motility or sperm density in the epididymis, there was a significant increase in the percentage of abnormal sperm in mice consuming 1.78 times the MHDD (based on a body surface comparison) and there was a reduction in the number of mating pairs producing a fifth litter at this dose, suggesting the potential for cumulative toxicity with chronic administration of acetaminophen near the upper limit of daily dosing

That optimized formulation contained a drug/polymer ratio of 1:10 with a 0.50% PVA concentration and a sonication time of 2 min (Puri et al., 2022)

Rare presentation of a treatable disorder: glutaric aciduria type 1