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GPX4 has been found to have three different forms of isoforms, namely mitochondrial type (MGPX4), cytoplasmic form (CGPX4), and sperm karyotype (SNGPX4) (Bersuker et al., 2019)

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In addition, examples from other biologic therapies, such as growth factors and gene therapy, that showed early promise but failed clinical translation underscore the importance of rigorous study design, safety monitoring, and realistic expectations in peptide research

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