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Description
[DOI] [PubMed] [Google Scholar] 8.Holmgren G., Meyer M.W., Chaney R.L., Daniels R.B
Current reliance on preclinical evidence underscores the urgent need for rigorous clinical trials
Overall, RONS-scavenging downregulates inflammatory cytokine levels to modulate M2 polarization mainly through the following mechanisms: (1) Significantly reducing the nuclear translocation of p65 NF-B by inhibiting IB phosphorylation, which inactivates the NF-B pathway to silence inflammatory genes, including iNOS [135, 136]
Epidermal Growth Factor (EGF): The Epidermal Growth Factor is linked with stimulating the growth of collagen and elastin fibers
Funding This work was supported by the China Postdoctoral Science Foundation Funded Project (2022M711722)
