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Acknowledgments Mohammed Al-Beltagi, Aysha Fakhroo, Fatima Al-Ali, Latifa Fakhroo, Marya Al-Hammadi, and Rania Snobar contributed equally to the work and should be considered co-first authors

It has been reported that H 2 S inhibits oxidative stress by activating SIRT1 signal transduction to protect airway from cigarette smoke damage in mice [36]