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For those with severe deficiencies, higher doses may be required initially to replenish B12 levels
For instance, in a TKI-induced lung cancer DTP cells model, TKI treatment was shown to indirectly induce phenotypic alterations in cancer-associated fibroblasts (CAFs), which enhance DTP cells survival via upregulation of NF-B and STAT3 signaling (Moghal et al., 2023)

Thus, in cysteinesulfinate-dependent pathways, sulfur is oxidized to a sulfinate prior to cleavage of the sulfur from the carbon chain or conversion to hypotaurine, as shown in Fig

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