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Environ Mol mutagenesis (2021) 62(3):21626

The vitamin can be stored in the liver for a long time, so it may take a few years for a deficiency to develop ( Summary Vitamin B12 is a water-soluble vitamin that plays an important role in brain function and red blood cell production

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Thus, dietary supplement B 12 supplementation at 500 to 1000 g per day allows pernicious anemia and certain other defects in B 12 absorption to be treated with daily oral megadoses of B 12 without any correction of the underlying absorption defects