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doi: 10.3389/fimmu.2018.00339 198 MorrisD.KhurasanyM.NguyenT.KimJ.GuilfordF.MehtaR.et al
Over the past few years, results from clinical trials of IMiDs in MM patients have shown that the presence of conferring resistance mutations, loss of gene copy and splice variants of cereblon are associated with resistance to IMiDs and worse clinical outcome 192,193

Under physiological or subtoxic lipid peroxidation rates, cells survive by upregulation of antioxidant pathways and proteins, whereas, at toxic concentration levels, cells induce apoptosis, eventually leading to cellular damage (32)
10.1007/s13311-018-0656-x 24 BelarbiK.CuvelierE.DesteeA.GressierB.Chartier-HarlinM

Shin-Ichiro Imal, Christopher M.Armstrong, Kaeberlein M, Guarente L
