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The dose for these shots is usually between 1000 mcg and 2500 mcg, given in the muscle

In rare cases where B12 is essential but acne remains intractable, dermatologists may consider oral isotretinoin, which in the UK can only be initiated by consultant dermatologists and requires strict monitoring, including a pregnancy prevention programme for women of childbearing potential

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Its arginate salt form and distinct nomenclature place it in a different regulatory category from the acetate form that received the FDA restriction